A few issues: I felt like the story got kind of confusing towards the end, although in my experience Obsidian’s stories get much better on subsequent playthroughs as you pick up on subtle things you overlooked before.
Also, lots of bugs during the final battle, but if you save regularly it shouldn’t be a problem.
But all in all, I’d have to say it’s the best game to come out this year.
[UPDATE: Note that when I say “finished”, I mean I played through the main story line and completed it one time. Because there are so many ways to play through it, and so many sidequests, it would be inaccurate to say that I have come anywhere close to seeing everything in the game.]